Assessment of a phenotypic algorithm to detect plasmid-mediated quinolone resistance in Enterobacteriaceae
نویسندگان
چکیده
منابع مشابه
Plasmid-mediated quinolone resistance: a multifaceted threat.
Although plasmid-mediated quinolone resistance (PMQR) was thought not to exist before its discovery in 1998, the past decade has seen an explosion of research characterizing this phenomenon. The best-described form of PMQR is determined by the qnr group of genes. These genes, likely originating in aquatic organisms, code for pentapeptide repeat proteins. These proteins reduce susceptibility to ...
متن کاملMechanism of plasmid-mediated quinolone resistance.
Quinolones are potent antibacterial agents that specifically target bacterial DNA gyrase and topoisomerase IV. Widespread use of these agents has contributed to the rise of bacterial quinolone resistance. Previous studies have shown that quinolone resistance arises by mutations in chromosomal genes. Recently, a multiresistance plasmid was discovered that encodes transferable resistance to quino...
متن کاملEmergence of plasmid-mediated quinolone resistance genes in Enterobacteriaceae isolated from chickens in China.
increase in the number of different qnr-positive serotypes was observed in 2007, although the total number of positive isolates was evenly distributed between 2003 and 2007 (Table 1). The qnrS1 variant was highly prevalent in Salmonella Corvallis supporting the results recently published from Denmark, the Netherlands and the UK. 2,6,8 The Danish study included a restricted set of Salmonella Cor...
متن کاملPrevalence of plasmid-mediated quinolone resistance.
Quinolone resistance encoded by the qnr gene and mediated by plasmid pMG252 was discovered in a clinical strain of Klebsiella pneumoniae that was isolated in 1994 at the University of Alabama at Birmingham Medical Center. The gene codes for a protein that protects DNA gyrase from quinolone inhibition and that belongs to the pentapeptide repeat family of proteins. The prevalence of the gene has ...
متن کاملDetection of plasmid-mediated quinolone resistance determinants and qnrS expression in Enterobacteriaceae clinical isolates.
INTRODUCTION Rapid dissemination of plasmid-mediated quinolone resistance (PMQR) has been reported in clinical isolates. METHODOLOGY A total of 149 clinical isolates of Enterobacteriaceae were collected in Beijing and screened for PMQR genes using polymerase chain reaction (PCR). Real-time quantitative PCR was used to study the expression of qnrS. RESULTS The rates of qnr and aac(6')-Ib-cr ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2015
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkv392